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, Muhammad Muzammil Nazir Department of Zoology, Government College University , Faisalabad 38000, Pakistan Search for other works by this author on: Oxford Academic Sana Inam Department of Pharmaceutics, Government College University , Faisalabad 38000 , Pakistan Search for other works by this author on: Oxford Academic Muhammad Umar Ijaz Department of Zoology, Wildlife and Fisheries, University of Agriculture , Faisalabad 38040, Pakistan Search for other works by this author on: Oxford Academic Nimrah Zafar Department of Zoology, Government College University , Faisalabad 38000, Pakistan Search for other works by this author on: Oxford Academic Derya Karatas Yeni Department of Microbiology, University of Necmettin Erbakan , Konya, Turkey Search for other works by this author on: Oxford Academic Farkhanda Asad Department of Zoology, Government College University , Faisalabad 38000, Pakistan Search for other works by this author on: Oxford Academic Iqra Farzeen Department of Zoology, Government College University , Faisalabad 38000, Pakistan Search for other works by this author on: Oxford Academic Asma Ashraf Department of Zoology, Government College University , Faisalabad 38000, Pakistan Correspondence: Department of Zoology, Government College University, Faisalabad 38000, Pakistan. Email: asmabinm@gmail.com Search for other works by this author on: Oxford Academic
Journal of Pharmacy and Pharmacology, Volume 76, Issue 9, September 2024, Pages 1178–1198, https://doi.org/10.1093/jpp/rgae072
Published:
10 July 2024
Article history
Received:
02 March 2024
Accepted:
29 May 2024
Published:
10 July 2024
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Muhammad Muzammil Nazir, Sana Inam, Muhammad Umar Ijaz, Nimrah Zafar, Derya Karatas Yeni, Farkhanda Asad, Iqra Farzeen, Asma Ashraf, In vivo and in silico elucidation of possible potential and mechanisms involved in the analgesic action of ethanolic extract of Lavandula Stoechas, Journal of Pharmacy and Pharmacology, Volume 76, Issue 9, September 2024, Pages 1178–1198, https://doi.org/10.1093/jpp/rgae072
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Abstract
Objectives
Our research focused on plant’s ethanolic extract Lavandula stoechas flower part to investigate the potential analgesic effects and possible pathways involvements.
Methods
Four experimental tests were performed on Swiss albino mice with five animals in each group at different doses (50, 100, and 200mg/kg); formalin test, tail-flick test, acetic acid-induced writhing, and hot-plate test. The opioidergic, noradrenergic, cholinergic, and K channel blockers in the analgesic actions were also carried out for the potential route involvement.
Key finding
The percentage inhibition for abdominal writhing’s and formalin activity showed a dose-dependent manner for early and late phases reducing abdominal writhing’s and time period of licking, respectively. Tail immersion and hot-plate test demonstrated a substantial and dose-dependent increase in the latency time and time period of paw liking and jumping response respectively. GC–MS showed the abundantly present compounds were octadecatrienoic acid (34.35%), n-hexadecanoic acid (12.98%). In silico analyses have revealed three compounds that had good interactions with 6y3c receptor proteins, demonstrating strong binding affinities and satisfying docking parameters.
Conclusions
Overall, these studies showed that ethanolic extract of L. stoechas is an important medicinal plant, with both central and peripheral antinociceptive and analgesic activities supporting its traditional use for therapeutic purposes.
analgesic, cholinergic and K channel blockers, Lavandula, noradrenergic, opioid receptor, opioidergic, pain
© The Author(s) 2024. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
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In vivo and in silico elucidation of possible potential and mechanisms involved in the analgesic action of ethanolic extract of Lavandula Stoechas - 24 Hours access
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